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Breast CancerESMO 2023

EMBER-2 study: final results

22 October 2023

Prof Patrick Neven, gynaecological oncologist at University Hospital Leuven, summarizes the poster he presented.

A preoperative window-of-opportunity (WOO) study of imlunestrant in ER+, HER- early breast cancer (EBC): Final analysis from EMBER-2.

To administer ER inhibition preoperatively, the pharmacodynamic and safety profiles of Imlunestrant were examined. Among patients with ER-positive, and HER2-negative breast cancer, varying doses of Imlunestrant did not exhibit significant differences in pharmacodynamic biomarkers or tumour histology. The drug demonstrated favourable tolerability, thereby supporting the rationale for additional investigations.

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