Combining T-DXd with Radiation Therapy

In this video, Prof François Duhoux joins Dr Luca Visani, radiation oncologist at the University of Florence, to discuss the results of a poster looking into the combined use of trastuzumab deruxtecan (T-DXd) and radiation therapy in patients with metastatic breast cancer. For this analysis, data of 118 consecutive patients treated with T-DXd with or without RT were retrospectively evaluated. The presented preliminary data indicate that this combination is safe, without an increased rate of severe acute toxicity when patients receive concurrent RT. Importantly, no events of radionecrosis were reported among the 17 patients treated with intracranial radiotherapy. While being reassuring, data of larger patient series are necessary to confirm these findings. Until then, caution remains warranted when considering the concomitant use of T-DXd and radiotherapy.