Pragmatic recommendations for treating patients with myelofibrosis, particularly those experiencing cytopenias

Prof Claire Harrison, a haematologist at Guy’s and St. Thomas’ Hospital in London (UK), presents collaborative efforts involving colleagues and patients to offer pragmatic recommendations for treating patients with myelofibrosis, particularly those experiencing cytopenias.

Utilizing Modified Delphi technology driven by consensus, the process involved defining topics of unmet need and formulating agreed-upon recommendations. A steering committee, comprising global experts, and an extended faculty of over 30 individuals and representatives from patient advocacy organizations, were involved. The inclusion of patients in shaping these recommendations introduced a unique and essential perspective.

The study addressed various unmet needs in myelofibrosis, focusing on prognostic criteria, their selection, and timing. A comprehensive table is presented to summarize the applicable prognostic tools, accommodating scenarios where next-generation sequencing and an extended genetic profile might not be feasible.

Recommendations were crafted for managing critical areas of unmet need in patients, such as anaemia and thrombocytopenia. A structured approach for investigating and managing these patients was outlined. Additionally, the study identified key factors signalling the need to reconsider therapy, highlighting indicators of treatment ineffectiveness. Given the array of available therapy options, deciding when to change therapy can be challenging, and this work aims to assist colleagues internationally in navigating these decisions.

The next step involves preparing a publication and exploring additional communication methods to disseminate this valuable information.

Reference:

Harrison C, ASH2023. #2355

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