Cognitive and psychometric predictors of return to work after allo-HSCT

Quality of life plays a crucial role in the ability of long-term survivors of allogeneic stem cell transplantation (allo-HSCT) to return to work (RTW). The SOPRALLO project investigates long-term outcomes in patients who underwent allo-HSCT at the Jules Bordet Institute and remained in remission for at least one year posttransplant. This sub-analysis focuses on data from the Impact of Cancer version 2 and the FACT-Cog questionnaires, which assess QoL and cognitive function in cancer survivorship. Preliminary results indicate that negative psychological and emotional states adversely affect RTW outcomes. In contrast, higher perceived cognitive abilities are associated with improved RTW rates. Additional factors influencing RTW include self-image, anxiety, and the long-term psychosocial impacts of cancer. These findings highlight the complex interplay between psychological well-being and occupational reintegration. They underscore the need for structured support systems addressing emotional and cognitive challenges in post-HSCT survivors. Enhancing QoL may significantly facilitate successful RTW. Targeted interventions should prioritize mental health and cognitive rehabilitation.