A 46 long non-coding RNAs expression signature as independent prognostic factor in pediatric AML

Approximately 30% of pediatric AML patients encounter relapse, emphasizing the imperative need for refining risk stratification in this cohort. Consequently, Zhiyao Ren, PhD student at University Hospital Ghent, constructed a signature comprising 46 lncRNAs associated with relapse and assessed its prognostic efficacy for RFS in pediatric AML.

Internal validation substantiated the robust performance of the signature in predicting 1, 2, and 3-year RFS. Moreover, external validation across independent cohorts corroborated its prognostic utility, establishing the signature as an independent prognostic determinant. Intriguingly, our signature not only served as an independent predictor of RFS but also stratified patients into distinct risk groups, thereby diverging from conventional risk classification factors.

Reference:

Ren Z, ASH 2023. #1569

With the educational support of: